Development of Plasma Cell-Free DNA Assays for Early Cancer Detection: First Insights from the Circulating Cell- Free Genome Atlas (CCGA) Study

First CCGA Training Set

  • 2,800 participants sampled for first case-control sub-study
  • Training set (N=1,792) to develop classifiers of cancer vs. noncancer using rigorous crossvalidation
  • Test set (N=1,008) to test the classifiers
  • Analysis followed a pre-specified statistical analysis plan with clinical and assay data locked and blinded to each other