Supervisor/Manager, MSAT (Reagents Manufacturing)

Laboratory Operations
Raleigh-Durham, NC

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GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured.

GRAIL is using the power of high-intensity sequencing,population-scale clinical studies, and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology and to develop and commercialize pioneering products for the early detection of cancer.

We are seeking passionate and talented individuals to join us in realizing our mission, which has the potential to alleviate the global burden of cancer.

In search of the right opportunity for you? Apply to GRAIL to be considered for future roles!


Supervisor/Manager, MSAT (Reagents Manufacturing)

GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on alleviating the global burden of cancer by developing pioneering technology to detect and identify multiple deadly cancer types early. The company is using the power of next-generation sequencing, population-scale clinical studies, and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology, and to develop its multi-cancer early detection blood test. GRAIL is headquartered in Menlo Park, CA with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies. For more information, please visit www.grail.com.

GRAIL is seeking a Supervisor/Manager, Manufacturing Sciences and Technology (MSAT) to manage the MSAT team. You will be primarily responsible for leading, developing, and occasionally executing on materials manufacturing and associated tasks.  The MSAT team comprises the reagents Manufacturing and reagent Quality Control groups.  The ideal candidate is a detail-oriented, strong team player with vast experience in NGS assays and assay components.  The candidate will be expected to partner with many functions within the organization, inducing but not limited to Automation, Product Development, LIMS, Quality, Equipment Engineering and the Clinical Lab.  The candidate will be able to identify system limitations, implement process improvements, write documentation and be instrumental in the implementation and operation of the MSAT functions.

You Will:

  • Oversee the day to day operations of the MSAT and reagent QC groups in support of the Clinical Lab
  • Be an expert on the materials used in the current production assays and understand the implications for material failures
  • Assist in the development of new manufacturing and QC testing methods for reagents used in the Clinical Lab
  • Coordinating material readiness timing with Supply Chain and reagents QC
  • Receive and scale protocols from the Process Engineering team to enable efficient manufacturing and assay workflows
  • Investigate potential quality issues (both internal and external) and work with Quality to resolve Corrective and Preventative Actions (CAPA)
  • Uphold MSAT activity compliance with current Quality Systems including, but not limited to CLIA, CAP, FDA and ISO regulatory guidelines

Your Background Should Include:

  • B.S required, advanced degree strongly preferred in a relevant field.
  • 5+ years of experience in Next Generation Sequencing assays and workflows.
  • Experience with Automated sample preparation workflows.
  • Experience developing and executing QC test workflows is a plus.
  • Proven track record in recruiting, hiring, building and sustaining a high performing team
  • Proficient with basic molecular biology laboratory techniques including but not limited to (e.g. pipetting, SPRI, PCR, qPCR).
  • Familiarity with nucleic acids extraction techniques and quantification devices (e.g., Nanodrop, Bioanalyzer, Fragment Analyzer, ddPCR).
  • Excellent teamwork and collaboration skills.
  • Outstanding written and verbal communication skills.  
  • Self-directed, innovative, and creative thinker.
  • General computer skills and proficiency in G-Suite.

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We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.