Clinical Evidence

Our clinical programs are leading the field

Explore the scientific evidence supporting GRAIL’s multi-cancer early detection approach, including peer-reviewed publications and presentations at leading medical congresses. Together, these data highlight test performance, clinical utility, and progress toward transforming cancer screening.

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MANUSCRIPTS

PRESENTATIONS

Foundational data

Validation
CCGA

Case-control study

Annals of Oncology

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Clinical Performance
PATHFINDER 2

Prospective screening study

Nature Medicine

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Clinical Utility
NHS-Galleri

Randomized control study

Nature Medicine

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Performance in Medicare
Real-World Experience

Prospective real-world study

Nature Communications

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Featured evidence

Presentation

European Society for Medical 
Oncology (ESMO) 2025

Safety and Performance of a Multi-Cancer Early Detection (MCED) Test in an Intended Use Population: Initial Results from the Registrational PATHFINDER 2 Study

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Manuscript

JCO Precision Oncology

Prognostic Significance of Blood-Based Multicancer Detection in Circulating Tumor DNA: Five-Year Outcomes of Analysis

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Manuscript

Cancer Prevention Research

Molecular Cancer Signal Localization in MCED Testing Minimizes Radiation and Imaging Burden Compared with Whole-body Imaging Approaches

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Presentation

American Association of Cancer Research (AACR) 2026

Association Between Emergency Department (ED) Involvement in Cancer Diagnosis and Survival Across Cancer Types in the Medicare Population

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Manuscripts

PLOS ONE

Analytical validation of a multi-cancer early detection test with cancer signal origin using a cell-free DNA–based targeted methylation assay

April 14, 2023
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Cancer Epidemiology

Surgical resection as a predictor of cancer-specific survival by stage at diagnosis and cancer type, United States, 2006–2015

April 5, 2023
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Cancer

Modeled residual current cancer risk after clinical investigation of a positive multi-cancer early detection test result

March 21, 2023
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Lancet Public Health

Uptake of invitations to a lung health check offering low-dose CT lung cancer screening among an ethnically and socioeconomically diverse population at risk of lung cancer in the UK (SUMMIT): a prospective, longitudinal cohort study

February 24, 2023
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BMC Cancer

Cancer incidence in immunocompromised patients: a single-center cohort study

January 9, 2023
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Nature

A DNA methylation atlas of normal human cell types

January 4, 2023
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