Clinical Evidence

Our clinical programs are leading the field

Explore the scientific evidence supporting GRAIL’s multi-cancer early detection approach, including peer-reviewed publications and presentations at leading medical congresses. Together, these data highlight test performance, clinical utility, and progress toward transforming cancer screening.

Jump to:

MANUSCRIPTS

PRESENTATIONS

Foundational data

Validation
CCGA

Case-control study

Annals of Oncology

Read Full Article
Clinical Performance
PATHFINDER 2

Prospective screening study

Nature Medicine

Read Full Article
Clinical Utility
NHS-Galleri

Randomized control study

Nature Medicine

Read Full Article
Performance in Medicare
Real-World Experience

Prospective real-world study

Nature Communications

Read Full Article

Featured evidence

Presentation

European Society for Medical 
Oncology (ESMO) 2025

Safety and Performance of a Multi-Cancer Early Detection (MCED) Test in an Intended Use Population: Initial Results from the Registrational PATHFINDER 2 Study

See Presentation
Manuscript

JCO Precision Oncology

Prognostic Significance of Blood-Based Multicancer Detection in Circulating Tumor DNA: Five-Year Outcomes of Analysis

Read Full Article
Manuscript

Cancer Prevention Research

Molecular Cancer Signal Localization in MCED Testing Minimizes Radiation and Imaging Burden Compared with Whole-body Imaging Approaches

Read Full Article
Presentation

American Association of Cancer Research (AACR) 2026

Association Between Emergency Department (ED) Involvement in Cancer Diagnosis and Survival Across Cancer Types in the Medicare Population

See Presentation

Manuscripts

Preventive Medicine Reports

Breast, Colorectal, Lung, Prostate, and Cervical Cancer Screening Prevalence in a Large Commercial and Medicare Advantage Plan, 2008–2020

November 7, 2022
View Manuscript
European Respiratory Journal

Universal lung epithelium DNA methylation markers for detection of lung damage in liquid biopsies

November 3, 2022
View Manuscript
Tumori

Multi-cancer early detection test sensitivity for cancers with and without current population-level screening options

October 31, 2022
View Manuscript
Clinical and Translational Science

BLOODPAC: Collaborating to chart a path towards blood-based screening for early cancer detection

October 17, 2022
View Manuscript
Cancers

Cell-Free DNA–Based Multi-Cancer Early Detection Test in an Asymptomatic Screening Population (NHS-Galleri): Design of a Pragmatic, Prospective Randomised Controlled Trial

October 1, 2022
View Manuscript
Lung Cancer

Utilisation of primary care electronic patient records for identification and targeted invitation of individuals to a lung cancer screening programme

September 20, 2022
View Manuscript