Clinical Evidence

Our clinical programs are leading the field

Explore the scientific evidence supporting GRAIL’s multi-cancer early detection approach, including peer-reviewed publications and presentations at leading medical congresses. Together, these data highlight test performance, clinical utility, and progress toward transforming cancer screening.

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MANUSCRIPTS

PRESENTATIONS

Foundational data

Validation
CCGA

Case-control study

Annals of Oncology

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Clinical Performance
PATHFINDER 2

Prospective screening study

Nature Medicine

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Clinical Utility
NHS-Galleri

Randomized control study

Nature Medicine

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Performance in Medicare
Real-World Experience

Prospective real-world study

Nature Communications

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Featured evidence

Presentation

European Society for Medical 
Oncology (ESMO) 2025

Safety and Performance of a Multi-Cancer Early Detection (MCED) Test in an Intended Use Population: Initial Results from the Registrational PATHFINDER 2 Study

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Manuscript

JCO Precision Oncology

Prognostic Significance of Blood-Based Multicancer Detection in Circulating Tumor DNA: Five-Year Outcomes of Analysis

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Manuscript

Cancer Prevention Research

Molecular Cancer Signal Localization in MCED Testing Minimizes Radiation and Imaging Burden Compared with Whole-body Imaging Approaches

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Presentation

American Association of Cancer Research (AACR) 2026

Association Between Emergency Department (ED) Involvement in Cancer Diagnosis and Survival Across Cancer Types in the Medicare Population

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Manuscripts

European Journal of Health Economics

Health State Utility Values by Cancer Stage: A Systematic Literature Review

June 14, 2021
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Clinical Cancer Research

Prognostic Significance of Blood-Based Multi-cancer Detection in Plasma Cell-Free DNA

June 4, 2021
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Nature Communications

A Comprehensive Characterization of the Cell-free Transcriptome Reveals Tissue and Subtype-specific Biomarkers for Cancer Detection

April 21, 2021
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British Journal of Cancer

Transforming the landscape of early cancer detection using blood tests—Commentary on current methodologies and future prospects

February 9, 2021
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Cancer Cell

Multi-cancer early detection: a new paradigm for reducing cancer-specific and all-cause mortality

February 4, 2021
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CEBP

Modeled reductions in late-stage cancer with a multi-cancer early detection test

December 16, 2020
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