Clinical Evidence

Our clinical programs are leading the field

Explore the scientific evidence supporting GRAIL’s multi-cancer early detection approach, including peer-reviewed publications and presentations at leading medical congresses. Together, these data highlight test performance, clinical utility, and progress toward transforming cancer screening.

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MANUSCRIPTS

PRESENTATIONS

Foundational data

Validation
CCGA

Case-control study

Annals of Oncology

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Clinical Performance
PATHFINDER 2

Prospective screening study

Nature Medicine

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Clinical Utility
NHS-Galleri

Randomized control study

Nature Medicine

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Performance in Medicare
Real-World Experience

Prospective real-world study

Nature Communications

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Featured evidence

Presentation

European Society for Medical 
Oncology (ESMO) 2025

Safety and Performance of a Multi-Cancer Early Detection (MCED) Test in an Intended Use Population: Initial Results from the Registrational PATHFINDER 2 Study

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Manuscript

JCO Precision Oncology

Prognostic Significance of Blood-Based Multicancer Detection in Circulating Tumor DNA: Five-Year Outcomes of Analysis

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Manuscript

Cancer Prevention Research

Molecular Cancer Signal Localization in MCED Testing Minimizes Radiation and Imaging Burden Compared with Whole-body Imaging Approaches

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Presentation

American Association of Cancer Research (AACR) 2026

Association Between Emergency Department (ED) Involvement in Cancer Diagnosis and Survival Across Cancer Types in the Medicare Population

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Manuscripts

CEBP

Projected Reductions in Absolute Cancer–Related Deaths from Diagnosing Cancers Before Metastasis, 2006–2015

March 30, 2020
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Annals of Oncology

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

March 30, 2020
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Nature Medicine

High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants

November 25, 2019
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Annals of Oncology

Ultra-deep next-generation sequencing of plasma cell-free DNA in patients with advanced lung cancers: results from the Actionable Genome Consortium

March 20, 2019
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Cell

Next-Generation Sequencing of Circulating Tumor DNA for Early Cancer Detection

February 9, 2017
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