Clinical Evidence

Our clinical programs are leading the field

Explore the scientific evidence supporting GRAIL’s multi-cancer early detection approach, including peer-reviewed publications and presentations at leading medical congresses. Together, these data highlight test performance, clinical utility, and progress toward transforming cancer screening.

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MANUSCRIPTS

PRESENTATIONS

Foundational data

Validation
CCGA

Case-control study

Annals of Oncology

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Clinical Performance
PATHFINDER 2

Prospective screening study

Nature Medicine

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Clinical Utility
NHS-Galleri

Randomized control study

Nature Medicine

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Performance in Medicare
Real-World Experience

Prospective real-world study

Nature Communications

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Featured evidence

Presentation

European Society for Medical 
Oncology (ESMO) 2025

Safety and Performance of a Multi-Cancer Early Detection (MCED) Test in an Intended Use Population: Initial Results from the Registrational PATHFINDER 2 Study

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Manuscript

JCO Precision Oncology

Prognostic Significance of Blood-Based Multicancer Detection in Circulating Tumor DNA: Five-Year Outcomes of Analysis

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Manuscript

Cancer Prevention Research

Molecular Cancer Signal Localization in MCED Testing Minimizes Radiation and Imaging Burden Compared with Whole-body Imaging Approaches

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Presentation

American Association of Cancer Research (AACR) 2026

Association Between Emergency Department (ED) Involvement in Cancer Diagnosis and Survival Across Cancer Types in the Medicare Population

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Manuscripts

CEBP

Racial/ethnic differences in cancer diagnosed after metastasis: absolute burden and deaths potentially avoidable through earlier detection

November 19, 2021
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PLOS ONE

Clinical correlates of circulating cell-free DNA tumor fraction

August 25, 2021
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British Journal of Cancer

Estimating the population health impact of a multi-cancer early detection genomic blood test to complement existing screening in the US and UK

August 23, 2021
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Touch Oncology

Criteria for Evaluating Multi-cancer Early Detection Tests

July 15, 2021
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Cancers

The PATHFINDER Study: Assessment of the Implementation of an Investigational Multi-Cancer Early Detection Test into Clinical Practice

July 13, 2021
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Annals of Oncology

Clinical Validation of a Targeted Methylation-Based Multi-Cancer Early Detection Test Using an Independent Validation Set

June 24, 2021
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