Clinical Evidence

Our clinical programs are leading the field

Explore the scientific evidence supporting GRAIL’s multi-cancer early detection approach, including peer-reviewed publications and presentations at leading medical congresses. Together, these data highlight test performance, clinical utility, and progress toward transforming cancer screening.

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MANUSCRIPTS

PRESENTATIONS

Foundational data

Validation
CCGA

Case-control study

Annals of Oncology

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Clinical Performance
PATHFINDER 2

Prospective screening study

Nature Medicine

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Clinical Utility
NHS-Galleri

Randomized control study

Nature Medicine

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Performance in Medicare
Real-World Experience

Prospective real-world study

Nature Communications

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Featured evidence

Presentation

European Society for Medical 
Oncology (ESMO) 2025

Safety and Performance of a Multi-Cancer Early Detection (MCED) Test in an Intended Use Population: Initial Results from the Registrational PATHFINDER 2 Study

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Manuscript

JCO Precision Oncology

Prognostic Significance of Blood-Based Multicancer Detection in Circulating Tumor DNA: Five-Year Outcomes of Analysis

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Manuscript

Cancer Prevention Research

Molecular Cancer Signal Localization in MCED Testing Minimizes Radiation and Imaging Burden Compared with Whole-body Imaging Approaches

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Presentation

American Association of Cancer Research (AACR) 2026

Association Between Emergency Department (ED) Involvement in Cancer Diagnosis and Survival Across Cancer Types in the Medicare Population

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Manuscripts

Thorax

Telephone risk-based eligibility assessment for low-dose CT lung cancer screening

July 21, 2022
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The Patient

Patient Preferences for Multi-Cancer Early Detection (MCED) Screening Tests

July 18, 2022
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Lung Cancer

The reporting of pulmonary nodule results by letter in a lung cancer screening setting

April 20, 2022
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Current Medical Research and Opinion

Cost of cancer management by stage of diagnosis among Medicare beneficiaries

March 14, 2022
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BMC Cancer

Patient-reported outcomes associated with cancer screening: a systematic review

March 1, 2022
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Cancer Cell

New Genomic Technologies for Multi-Cancer Early Detection: Rethinking the Scope of Cancer Screening

February 3, 2022
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