Clinical Evidence

Our clinical programs are leading the field

Explore the scientific evidence supporting GRAIL’s multi-cancer early detection approach, including peer-reviewed publications and presentations at leading medical congresses. Together, these data highlight test performance, clinical utility, and progress toward transforming cancer screening.

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MANUSCRIPTS

PRESENTATIONS

Foundational data

Validation
CCGA

Case-control study

Annals of Oncology

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Clinical Performance
PATHFINDER 2

Prospective screening study

Nature Medicine

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Clinical Utility
NHS-Galleri

Randomized control study

Nature Medicine

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Performance in Medicare
Real-World Experience

Prospective real-world study

Nature Communications

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Featured evidence

Presentation

European Society for Medical 
Oncology (ESMO) 2025

Safety and Performance of a Multi-Cancer Early Detection (MCED) Test in an Intended Use Population: Initial Results from the Registrational PATHFINDER 2 Study

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Manuscript

JCO Precision Oncology

Prognostic Significance of Blood-Based Multicancer Detection in Circulating Tumor DNA: Five-Year Outcomes of Analysis

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Manuscript

Cancer Prevention Research

Molecular Cancer Signal Localization in MCED Testing Minimizes Radiation and Imaging Burden Compared with Whole-body Imaging Approaches

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Presentation

American Association of Cancer Research (AACR) 2026

Association Between Emergency Department (ED) Involvement in Cancer Diagnosis and Survival Across Cancer Types in the Medicare Population

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Manuscripts

Clinical and Translational Science

Lexicon for blood-based early detection and screening: BLOODPAC consensus document

August 29, 2024
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JCO Precision Oncology

A Targeted Methylation–Based Multicancer Early Detection Blood Test Preferentially Detects High-Grade Prostate Cancer While Minimizing Overdiagnosis of Q:1 Indolent Disease

August 29, 2024
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Future Oncology

Leveraging multi-cancer blood tests to improve diagnostic efficiency for patients with nonspecific signs and symptoms

August 28, 2024
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British Journal of Cancer

Intention to have blood-based multi-cancer early detection (MCED) screening: a cross-sectional population-based survey in England

August 27, 2024
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Current Medical Research and Opinion

Modeling the population health impact of incorporating a multi-cancer early detection (MCED) test to existing cancer screening among immunocompromised individuals

August 17, 2024
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Health Affairs Scholar

Perceptions of multi-cancer early detection tests among communities facing barriers to health care

August 16, 2024
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