Clinical Evidence

Our clinical programs are leading the field

Explore the scientific evidence supporting GRAIL’s multi-cancer early detection approach, including peer-reviewed publications and presentations at leading medical congresses. Together, these data highlight test performance, clinical utility, and progress toward transforming cancer screening.

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MANUSCRIPTS

PRESENTATIONS

Foundational data

Validation
CCGA

Case-control study

Annals of Oncology

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Clinical Performance
PATHFINDER 2

Prospective screening study

Nature Medicine

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Clinical Utility
NHS-Galleri

Randomized control study

Nature Medicine

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Performance in Medicare
Real-World Experience

Prospective real-world study

Nature Communications

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Featured evidence

Presentation

European Society for Medical 
Oncology (ESMO) 2025

Safety and Performance of a Multi-Cancer Early Detection (MCED) Test in an Intended Use Population: Initial Results from the Registrational PATHFINDER 2 Study

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Manuscript

JCO Precision Oncology

Prognostic Significance of Blood-Based Multicancer Detection in Circulating Tumor DNA: Five-Year Outcomes of Analysis

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Manuscript

Cancer Prevention Research

Molecular Cancer Signal Localization in MCED Testing Minimizes Radiation and Imaging Burden Compared with Whole-body Imaging Approaches

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Presentation

American Association of Cancer Research (AACR) 2026

Association Between Emergency Department (ED) Involvement in Cancer Diagnosis and Survival Across Cancer Types in the Medicare Population

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Manuscripts

Journal of Medical Screening

Strong association between reduction of late-stage cancers and reduction of cancer-specific mortality in meta-regression of randomized screening trials across multiple cancer types

May 26, 2024
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Cancer Letter

Prognostic Implication of Methylation-Based Circulating Tumor DNA Detection Prior to Surgery in Stage I Non-Small Cell Lung Cancer

May 24, 2024
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Computerized Medical Imaging and Graphics

Enhancing cancer prediction in challenging screen-detected incident lung nodules using time-series deep learning

May 20, 2024
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NPJ Precision Oncology

A multi-cancer early detection blood test using machine learning detects early-stage cancers lacking USPSTF-recommended screening

April 17, 2024
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Social Science & Medicine

Attitudes to multi-cancer early detection (MCED) blood tests for population-based screening: A qualitative study in Great Britain

March 12, 2024
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J Epidemiol Community Health

Impact of screening participation on modelled mortality benefits of a multi-cancer early detection test by socioeconomic group in England

March 1, 2024
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